… Digoxin verapamil and quinidine are substrates of P-glycoprotein and verapamil and quinidine
inhibit the clearance of digoxin … amiodarone combined with digoxin increases the digoxin …

… frailty is not synonymous with ageing and the high heterogeneity in older age populations
should … ‘Do not do this’ Scientific evidence or general agreement not to use or recommend a …

… and concomitant use of drugs like Amiodarone, Quinidine and Verapamil may affect the
Digoxin clearance. In terms of excretion, 50-70% of Digoxin is excreted unchanged by renal, …

… The most commonly used lipid lowering treatments including all statins and fibrates but not …
blockers including verapamil and diltiazem; and amiodarone, digoxin, and quinidine have seri…

… be exercised as certain medications, such as amiodarone, diltiazem, verapamil, and quinidine,
can elevate digoxin levels in the bloodstream. Digoxin levels are used as a good toxicity …

… dataset was 178% for digoxin in the presence of quinidine. … amiodarone and spironolactone,
increasing digoxin AUC by … involved the inhibitor verapamil, increasing digoxin AUC by 41 …

… ‑ tial arrhythmogenicity of quinidine is the most relevant issue… amiodarone from other
AADs is the late onset of effect, … (verapamil and diltiazem) as class IV, and digoxin as class V …

… are recognised P-gp substrates [6, 55]. Indeed, verapamil, quinidine, dronedarone and
amiodarone … %, while digoxin or atorvastatin had relatively minor effects on the pharmacokinetic …

… (cetirizine, fexofenadine, verapamil, amiodarone, digoxin, quinidine and loperamide) ranged
… Prior to this study, the brain distribution of digoxin using discrete dosing in one monkey was …

… ), verapamil (nor-verapamil), Quinidine (3-OH quinidine), … that the increased bioavailability
of amiodarone is due to the … P-gp transporters, digoxin level can be attenuated by GM as …